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1:

Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways.

Agbottah E, Yeh WI, Berro R, Klase Z, Pedati C, Kehn-Hall K, Wu W, Kashanchi F.

AIDS Res Ther. 2008 Jun 10;5:12.

PMID: 18544167 [PubMed]

2:

Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells.

Mori N, Yamada Y, Ikeda S, Yamasaki Y, Tsukasaki K, Tanaka Y, Tomonaga M, Yamamoto N, Fujii M.

Blood. 2002 Sep 1;100(5):1828-34.

PMID: 12176906 [PubMed - indexed for MEDLINE]

3:

Human T-cell leukemia virus type I tax protein induces the expression of anti-apoptotic gene Bcl-xL in human T-cells through nuclear factor-kappaB and c-AMP responsive element binding protein pathways.

Mori N, Fujii M, Cheng G, Ikeda S, Yamasaki Y, Yamada Y, Tomonaga M, Yamamoto N.

Virus Genes. 2001 Jun;22(3):279-87.

PMID: 11450946 [PubMed - indexed for MEDLINE]

4:

Inhibition of HTLV-1 transcription by cyclin dependent kinase inhibitors.

Wang L, Deng L, Wu K, de la Fuente C, Wang D, Kehn K, Maddukuri A, Baylor S, Santiago F, Agbottah E, Trigon S, Morange M, Mahieux R, Kashanchi F.

Mol Cell Biochem. 2002 Aug;237(1-2):137-53.

PMID: 12236581 [PubMed - indexed for MEDLINE]

5:

Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-kappaB, as a strategy for chemoprevention and therapy of adult T-cell leukemia.

Watanabe M, Ohsugi T, Shoda M, Ishida T, Aizawa S, Maruyama-Nagai M, Utsunomiya A, Koga S, Yamada Y, Kamihira S, Okayama A, Kikuchi H, Uozumi K, Yamaguchi K, Higashihara M, Umezawa K, Watanabe T, Horie R.

Blood. 2005 Oct 1;106(7):2462-71. Epub 2005 Jun 14.

PMID: 15956280 [PubMed - indexed for MEDLINE]

6:

Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells.

Tomita M, Kawakami H, Uchihara JN, Okudaira T, Masuda M, Takasu N, Matsuda T, Ohta T, Tanaka Y, Ohshiro K, Mori N.

Int J Cancer. 2006 Feb 1;118(3):765-72.

PMID: 16106398 [PubMed - indexed for MEDLINE]

7:

Apoptosis induced by the histone deacetylase inhibitor FR901228 in human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells.

Mori N, Matsuda T, Tadano M, Kinjo T, Yamada Y, Tsukasaki K, Ikeda S, Yamasaki Y, Tanaka Y, Ohta T, Iwamasa T, Tomonaga M, Yamamoto N.

J Virol. 2004 May;78(9):4582-90.

PMID: 15078940 [PubMed - indexed for MEDLINE]

8:

Expression of FAP-1 (Fas-associated phosphatase) and resistance to Fas-mediated apoptosis in T cell lines derived from human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients.

Arai M, Kannagi M, Matsuoka M, Sato T, Yamamoto N, Fujii M.

AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):261-7.

PMID: 9491917 [PubMed - indexed for MEDLINE]

9:

Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NF-kappaB.

Okamoto K, Fujisawa J, Reth M, Yonehara S.

Genes Cells. 2006 Feb;11(2):177-91.

PMID: 16436054 [PubMed - indexed for MEDLINE]

10:

Overexpression of p21(waf1) in human T-cell lymphotropic virus type 1-infected cells and its association with cyclin A/cdk2.

de La Fuente C, Santiago F, Chong SY, Deng L, Mayhood T, Fu P, Stein D, Denny T, Coffman F, Azimi N, Mahieux R, Kashanchi F.

J Virol. 2000 Aug;74(16):7270-83.

PMID: 10906181 [PubMed - indexed for MEDLINE]

11:

Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.

Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC.

Mol Cell Biol. 1998 Sep;18(9):5157-65.

PMID: 9710600 [PubMed - indexed for MEDLINE]

12:

Transactivation of the interleukin-1alpha promoter by human T-cell leukemia virus type I and type II Tax proteins.

Mori N, Prager D.

Blood. 1996 Apr 15;87(8):3410-7.

PMID: 8605359 [PubMed - indexed for MEDLINE]

13:

HTLV-I Tax related dysfunction of cell cycle regulators and oncogenesis of adult T cell leukemia.

Arima N, Tei C.

Leuk Lymphoma. 2001 Jan;40(3-4):267-78. Review.

PMID: 11426548 [PubMed - indexed for MEDLINE]

14:

Mediators of central nervous system damage during the progression of human T-cell leukemia type I-associated myelopathy/tropical spastic paraparesis.

Barmak K, Harhaj EW, Wigdahl B.

J Neurovirol. 2003 Oct;9(5):522-9. Review.

PMID: 13129766 [PubMed - indexed for MEDLINE]

15:

Histone deacetylase inhibitors induce growth arrest and apoptosis of HTLV-1-infected T-cells via blockade of signaling by nuclear factor kappaB.

Nishioka C, Ikezoe T, Yang J, Komatsu N, Bandobashi K, Taniguchi A, Kuwayama Y, Togitani K, Koeffler HP, Taguchi H.

Leuk Res. 2008 Feb;32(2):287-96. Epub 2007 Jul 20.

PMID: 17644177 [PubMed - indexed for MEDLINE]

16:

HTLV-1 tax-induced NF-kappaB activation is synergistically enhanced by 12-O-tetradecanoylphorbol-13-acetate: mechanism and implications for Tax oncogenicity.

Azran-Shaish I, Tabakin-Fix Y, Huleihel M, Bakhanashvili M, Aboud M.

J Mol Med. 2008 Jul;86(7):799-814. Epub 2008 Apr 19.

PMID: 18425496 [PubMed - in process]

17:

Human T-cell leukemia virus type I tax activates transcription of the human monocyte chemoattractant protein-1 gene through two nuclear factor-kappaB sites.

Mori N, Ueda A, Ikeda S, Yamasaki Y, Yamada Y, Tomonaga M, Morikawa S, Geleziunas R, Yoshimura T, Yamamoto N.

Cancer Res. 2000 Sep 1;60(17):4939-45.

PMID: 10987310 [PubMed - indexed for MEDLINE]

18:

Resistance to Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis and constitutive expression of Apo2L/TRAIL in human T-cell leukemia virus type 1-infected T-cell lines.

Matsuda T, Almasan A, Tomita M, Uchihara JN, Masuda M, Ohshiro K, Takasu N, Yagita H, Ohta T, Mori N.

J Virol. 2005 Feb;79(3):1367-78.

PMID: 15650163 [PubMed - indexed for MEDLINE]

20:

Human T-cell leukemia virus type I Tax transactivates the matrix metalloproteinase-9 gene: potential role in mediating adult T-cell leukemia invasiveness.

Mori N, Sato H, Hayashibara T, Senba M, Hayashi T, Yamada Y, Kamihira S, Ikeda S, Yamasaki Y, Morikawa S, Tomonaga M, Geleziunas R, Yamamoto N.

Blood. 2002 Feb 15;99(4):1341-9.

PMID: 11830485 [PubMed - indexed for MEDLINE]

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