Pre-clinical development as microbicide of zinc tetra-ascorbo-camphorate, a novel terpenoid derivative: potent in vitro inhibitory activity against both R5- and X4-tropic HIV-1 strains without significant in vivo mucosal toxicity.

Saïdi H, Jenabian MA, Gombert B, Charpentier C, Mannarini A, Bélec L.

AIDS Res Ther. 2008 Jun 3;5:10.

PMID: 18522743 [PubMed]

Related Articles Free article in PMC

Infection of macrophages and dendritic cells with primary R5-tropic human immunodeficiency virus type 1 inhibited by natural polyreactive anti-CCR5 antibodies purified from cervicovaginal secretions.

Eslahpazir J, Jenabian MA, Bouhlal H, Hocini H, Carbonneil C, Grésenguet G, Kéou FX, LeGoff J, Saïdi H, Requena M, Nasreddine N, de Dieu Longo J, Kaveri SV, Bélec L.

Clin Vaccine Immunol. 2008 May;15(5):872-84. Epub 2008 Mar 19.

PMID: 18353923 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Preclinical evaluation of synthetic -2 RANTES as a candidate vaginal microbicide to target CCR5.

Kish-Catalone TM, Lu W, Gallo RC, DeVico AL.

Antimicrob Agents Chemother. 2006 Apr;50(4):1497-509.

PMID: 16569870 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Differential modulation of human lactoferrin activity against both R5 and X4-HIV-1 adsorption on epithelial cells and dendritic cells by natural antibodies.

Saidi H, Eslahpazir J, Carbonneil C, Carthagena L, Requena M, Nassreddine N, Belec L.

J Immunol. 2006 Oct 15;177(8):5540-9. Erratum in: J Immunol. 2006 Dec 15;177(12):8879. Eslaphazir, Jobin [corrected to Eslahpazir, Jobin].

PMID: 17015741 [PubMed - indexed for MEDLINE]

Related Articles

Candidate microbicide PPCM blocks human immunodeficiency virus type 1 infection in cell and tissue cultures and prevents genital herpes in a murine model.

Mesquita PM, Wilson SS, Manlow P, Fischetti L, Keller MJ, Herold BC, Shattock RJ.

J Virol. 2008 Jul;82(13):6576-84. Epub 2008 Apr 23.

PMID: 18434407 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants.

Fletcher PS, Wallace GS, Mesquita PM, Shattock RJ.

Retrovirology. 2006 Aug 1;3:46.

PMID: 16882346 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2-/- gammac -/- (RAG-hu) mice.

Berges BK, Akkina SR, Folkvord JM, Connick E, Akkina R.

Virology. 2008 Apr 10;373(2):342-51. Epub 2008 Jan 18.

PMID: 18207484 [PubMed - indexed for MEDLINE]

Related Articles

Stampidine is a potential nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide.

D'Cruz OJ, Uckun FM.

Fertil Steril. 2004 Mar;81 Suppl 1:831-41.

PMID: 15019817 [PubMed - indexed for MEDLINE]

Related Articles

Mucosal toxicity studies of a gel formulation of native pokeweed antiviral protein.

D'Cruz OJ, Waurzyniak B, Uckun FM.

Toxicol Pathol. 2004 Mar-Apr;32(2):212-21.

PMID: 15200159 [PubMed - indexed for MEDLINE]

Related Articles

Preclinical assessment of the proinflammatory potential of microbicide candidates.

Doncel GF, Chandra N, Fichorova RN.

J Acquir Immune Defic Syndr. 2004 Oct;37 Suppl 3:S174-80.

PMID: 16419269 [PubMed - indexed for MEDLINE]

Related Articles

Inhibition of HIV-1 infection by the candidate microbicide, dapivirine, a non-nucleoside reverse transcriptase inhibitor.

Fletcher P, Harman S, Azijn H, Armanasco N, Manlow P, Perumal D, de Bethune MP, Nuttall J, Romano J, Shattock R.

Antimicrob Agents Chemother. 2008 Nov 24. [Epub ahead of print]

PMID: 19029331 [PubMed - as supplied by publisher]

Related Articles

Tropism-independent protection of macaques against vaginal transmission of three SHIVs by the HIV-1 fusion inhibitor T-1249.

Veazey RS, Ketas TA, Klasse PJ, Davison DK, Singletary M, Green LC, Greenberg ML, Moore JP.

Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10531-6. Epub 2008 Jul 22.

PMID: 18647836 [PubMed - indexed for MEDLINE]

Related Articles

Differential in vitro inhibitory activity against HIV-1 of alpha-(1-3)- and alpha-(1-6)-D-mannose specific plant lectins: implication for microbicide development.

Saïdi H, Nasreddine N, Jenabian MA, Lecerf M, Schols D, Krief C, Balzarini J, Bélec L.

J Transl Med. 2007 Jun 12;5:28.

PMID: 17565674 [PubMed]

Related Articles Free article in PMC

CADA, a potential anti-HIV microbicide that specifically targets the cellular CD4 receptor.

Vermeire K, Brouwers J, Van Herrewege Y, Le Grand R, Vanham G, Augustijns P, Bell TW, Schols D.

Curr HIV Res. 2008 May;6(3):246-56.

PMID: 18473788 [PubMed - indexed for MEDLINE]

Related Articles

Mucosal safety of PHI-443 and stampidine as a combination microbicide to prevent genital transmission of HIV-1.

D'Cruz OJ, Uckun FM.

Fertil Steril. 2007 Oct;88(4 Suppl):1197-206. Epub 2007 May 11.

PMID: 17498709 [PubMed - indexed for MEDLINE]

Related Articles

Molecular umbrellas: a novel class of candidate topical microbicides to prevent human immunodeficiency virus and herpes simplex virus infections.

Madan RP, Mesquita PM, Cheshenko N, Jing B, Shende V, Guzman E, Heald T, Keller MJ, Regen SL, Shattock RJ, Herold BC.

J Virol. 2007 Jul;81(14):7636-46. Epub 2007 May 9.

PMID: 17494078 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

The nonnucleoside reverse transcriptase inhibitor UC-781 inhibits human immunodeficiency virus type 1 infection of human cervical tissue and dissemination by migratory cells.

Fletcher P, Kiselyeva Y, Wallace G, Romano J, Griffin G, Margolis L, Shattock R.

J Virol. 2005 Sep;79(17):11179-86.

PMID: 16103169 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Inhibitory effect of PRO 2000, a candidate microbicide, on dendritic cell-mediated human immunodeficiency virus transfer.

Teleshova N, Chang T, Profy A, Klotman ME.

Antimicrob Agents Chemother. 2008 May;52(5):1751-8. Epub 2008 Mar 10.

PMID: 18332174 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide.

Emau P, Tian B, O'keefe BR, Mori T, McMahon JB, Palmer KE, Jiang Y, Bekele G, Tsai CC.

J Med Primatol. 2007 Aug;36(4-5):244-53.

PMID: 17669213 [PubMed - indexed for MEDLINE]

Related Articles

Role of seminal plasma in the anti-HIV-1 activity of candidate microbicides.

Neurath AR, Strick N, Li YY.

BMC Infect Dis. 2006 Oct 16;6:150.

PMID: 17042959 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC