Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities.
Rusconi S, Moonis M, Merrill DP, Pallai PV, Neidhardt EA, Singh SK, Willis KJ, Osburne MS, Profy AT, Jenson JC, Hirsch MS.
Infectious Disease Unit, Massachusetts General Hospital, Boston 02114, USA.
PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have activity against human immunodeficiency virus type 1 in H9 cells, peripheral blood mononuclear cells, and primary monocyte/macrophages, are synergistic with zidovudine, and do not inhibit tetanus toxoid-stimulated T-cell proliferation at anti-human immunodeficiency virus type 1 concentrations.
Publication Types:
PMID: 8787913 [PubMed - indexed for MEDLINE]PMCID: PMC163090