AIDS Research and Therapy

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Management of HIV-1 associated hepatitis in patients with acquired immunodeficiency syndrome: role of a successful control of viral replication

Antonella Esposito1, Valentina Conti1, Maria Cagliuso1, Daniele Pastori2, Alessandra Fantauzzi1 and Ivano Mezzaroma1*

Author Affiliations

1 Department of Clinical Medicine, "Sapienza"- University of Rome, Rome, Italy

2 Department of Experimental Medicine, "Sapienza"- University of Rome, Rome, Italy

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AIDS Research and Therapy 2011, 8:9 doi:10.1186/1742-6405-8-9

Published: 1 March 2011

Abstract

In HIV-1 infected patients, increase of liver enzymes may be mainly due to viral coinfections, alcohol intake, hepatotoxic drugs or autoimmune diseases. Three cases of aminotransferase elevation occurred during a phase of uncontrolled viral replication combined with a severe immunodeficiency and resolved by an effective HAART are described, focusing on the etio-pathogenetic role possibly played by HIV-1 infection.