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Open Access Short report

Treatment of hypertriglyceridemia and HIV: fenofibrate-induced changes in the expression of chemokine genes in circulating leukocytes

Carlos Alonso-Villaverde*, Gerard Aragonès, Raúl Beltrán-Debón, Laura Fernández-Sender, Anna Rull, Jordi Camps, Josep M Alegret and Jorge Joven

Author Affiliations

Centre de Recerca Biomèdica, Hospital Universitari Sant Joan, IISPV, Universitat Rovira i Virgili, Sant Joan s/n, 43201 Reus, Spain

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AIDS Research and Therapy 2009, 6:26  doi:10.1186/1742-6405-6-26

Published: 23 November 2009

Abstract

Fenofibrate changed the expression of chemokine genes in circulating leukocytes of HIV-infected patients with hypertriglyceridemia. The data suggest that fenofibrate when effective in the treatment of lipoprotein abnormalities, may act as a modulator of systemic inflammation. This particular action, therefore, may also influence the clinical course of the disease.