AIDS Research and Therapy Volume 5
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 Case reportThe prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcomaL Feller1 , JN Masipa2 , NH Wood1 , EJ Raubenheimer3 and J Lemmer1  1Department of Periodontology and Oral Medicine, University of Limpopo School of Dentistry, Pretoria, South Africa 2Department of Maxillofacial and Oral Surgery, University of Limpopo School of Dentistry, Pretoria, South Africa 3Department of Oral Pathology, University of Limpopo School of Dentistry, Pretoria, South Africa author email corresponding author email
AIDS Research and Therapy 2008,
5:2doi:10.1186/1742-6405-5-2
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| Published: |
29 January 2008 |
Abstract
Background
Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to cause HIV-KS, the development of which is influenced by HIV, by increased production of cytokines and by growth factors. Whether HIV-KS is a true malignancy or a reactive hyperplastic inflammatory condition is debatable.
Results and Conclusion
Oedema of the face, legs and hands is a prominent feature of HIV-KS and is probably caused by lymphoedema related to the HIV-KS lesions. The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported. Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis. |