|
Clinical factors associated with the development of IRIS† |
|
| Risk factor |
Reference |
|
|
|
| Male sex |
[31] |
| Younger age |
[32] |
| Lower CD4 cell count at ART initiation |
[4] |
| Higher HIV RNA at ART initiation |
[4] |
| Lower CD4 cell percentage at ART initiation |
[32] |
| Lower CD4:CD8 ratio at ART initiation |
[32] |
| More rapid initial fall in HIV RNA on ART |
[31] |
| Antiretroviral naïve at time of OI diagnosis |
[31] |
| Shorter interval between OI therapy initiation and ART initiation |
[31] |
|
†Derived from cohorts where IRIS due to multiple pathogens were reported (i.e. cohorts which examined only TB-IRIS were excluded) | |
Murdoch et al. AIDS Research and Therapy 2007 4:9 doi:10.1186/1742-6405-4-9 |
|