Table 1

Variations in HLA-G DNA sequence observed among HIV-1-transmitting and non-transmitting mother-child pairs.
Exons
 Codons
 Nucleotide positions
Nucleotide substitutions*
 Amino acid changes
5'URR
 ---
 634 C/G
 C→G
 None
5'URR
 ---
 714 ins T,G
 insT,G
 None
2 α-1-domain
 31
 1074 A/T
 A→T
 Thr-to-Ser
2 α-1-domain
 57
 1154 G/A
 G→A
 Pro-to-Pro
3 α-2-domain
 93
 1486 C/G
 C→G
 His-to-Asp
3 α-2-domain
 93
 1486 C/A
 C→A
 His-to-Asp
3 α-2-domain
 93
 1488 C/T
 C→T
 None (His)
3 α-2-domain
 107
 1528 G/A
 G→A
 Gly-to-Arg
3 α-2-domain
 110
 1537 C/A
 C→A
 Leu-to-Ile
3 α-2-domain
 130
 1597 del C
 del C
 Leu→frameshift
4 α-3-domain
 256
 2575 G/A
 G→A
 Arg-to-Lys
4 α-3-domain
 257
 2577 T/A
 T→A
 Tyr-to-Asn
4 α-3-domain
 269
 2614 C/A
 C→A
 Pro-to-His
4 α-3-domain
 272
 2622 C/A
 C→A
 Leu-to-Met
Intron 6
3401 ins C
 ins C
 None
Intron 7
3579 G/A
 G→A
 None


3585 G/T
 G→T
 None


3619 C/G
 C→G
 None
8 (3'UTR)
3742 T/A
 T→A
 instability of mRNA
8 (3'UTR)
3743 C/T
 Del 14 bp
 instability of mRNA
8 (3'UTR)
3777 G/C
 G→C
 instability of mRNA

*Polymorphisms are indicated with reference to the wild-type HLA 6.0 sequence previously published by Geraghty (1987).

Aikhionbare et al. AIDS Research and Therapy 2006 3:28   doi:10.1186/1742-6405-3-28
Open Data