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Open Access Short report

Compare mDCs and pDCs between two distinct patients groups in acute HIV-1 infection

Yanmei Jiao, Xin Sun, Xiaojie Huang, Wei Li, Tong Zhang* and Hao Wu*

Author Affiliations

Center for Infectious Diseases, Beijing You-an Hospital, Capital Medical University, Beijing 100069, China

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AIDS Research and Therapy 2014, 11:22  doi:10.1186/1742-6405-11-22

Published: 31 July 2014

Abstract

The role of DCs in primary HIV-1 infection remains uncertain. In this study, we enrolled two different groups of subjects with acute HIV-1 infection. One group progressed to CD4 counts below 200 cells/μl within 2 years of HIV-1 infection (CD4 Low Group), while the other group maintained CD4 counts above 500 cells/μl (CD4 High Group). We did not find statistical difference in the pDC number between the two groups during acute HIV-1 infection. However, the mDC number was significantly lower in the CD4 Low Group than in the CD4 High Group.

Keywords:
Acute HIV-1 infection; DCs; Rapid disease progression