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Open Access Short report

Prophylactic and therapeutic effect of AZT/3TC in RT-SHIV infected Chinese-origin rhesus macaques

Wei Wang1234, Nan Yao1, Zhe Cong1234, Hong Jiang1234, Chuan Qin1234* and Qiang Wei1234*

Author Affiliations

1 Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing 100021, China

2 Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences(CAMS), Beijing 100021, China

3 Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Beijing 100021, China

4 Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing 100021, China

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AIDS Research and Therapy 2014, 11:12  doi:10.1186/1742-6405-11-12

Published: 4 March 2014

Abstract

Background

The precise efficacy of nucleoside analogue reverse-transcriptase inhibitors (NRTIs) in preventing and inhibiting virus replication remains unknown in RT-SHIV infected Chinese-origin rhesus macaques (Ch RM).

Findings

Ch RM were inoculated intravenously with 200 TCID50 RT-SHIV and treated by gavage with NRTIs (20 mg AZT and 10 mg 3TC twice per day) for four consecutive weeks beginning at one hour, on day 217 or 297 post inoculation, respectively. Treatment with AZT/3TC inhibited transiently RT-SHIV replication during chronic infection, but did not significantly affect peripheral blood CD4+ T cells in macaques. Treatment with AZT/3TC at 1 hour post infection prevented RT-SHIV infection in two out of four animals during the 120-day observation period.

Conclusions

Therefore, the Ch RM model with RT-SHIV infection can be used to evaluate the efficacy of new NRTIs.

Keywords:
RT-SHIV; Animal model; Chinese-origin rhesus macaque; Post-exposure prophylaxis; Therapy